Dinosaur Comics: You've heard of this one, right? I think it's not so much a comic as it is a very funny, very interesting blog that happens to be wrapped around some pictures of dinosaurs. I get lost for hours clicking the random strip button.
Penny Arcade: Located on livejournal at pennyarcaderss (Just comics) or pennyarcaderss (full site feed). These guys are either on or they are off. When they are on, the comic is very funny. When they are off, I usually am just confused by the comic. It's on enough to check it on a regular basis, though.
Saturday Morning Breakfast Cereal is the most underrated comic I have seen online. How that is possible, I'm not sure. Read this one for a while and you will want to bookmark it for sure.
modrnwrld_comic: You know This Modern World, right? I used to read this comic in the stranger, but they don't carry it anymore. Online is the only place I know to get it now, and thankfully, it's on livejournal. Hooray!
POKEY THE PENGUIN!!: Non-sequitur at it's finest.
Sinfest: I think this might have been the first online comic that I loved.
redmeat_rss: Red Meat is, um, totally worth reading as well. :)
someposifeed: Something Positive is one of the most continuously entertaining comics out there. Always pushing some limit of taste, the entire catalog is worth reading through.
spamusement is funny enough to keep on your friendslist. I don't think it's as brilliant as some other people may have hailed it, but it's definitely clever.
calvinhobbesurl: Calvin and Hobbes, y0.
Alien Loves Predator is a silly action figure comic. Lots of the jokes are New York jokes which are lost on my Seattle brain, but it's still pretty good.
Chugworth Academy: The jury is still out on this one. The story is ok, the humor isn't very funny, but the artwork is very neat, in an anime kinda way.
8-bit Theater: I stopped reading this one for a long while, but I'm trying to catch up. Only like 200 comics to go!
RPG World: ditto with this comic.
Which ones did I miss? Which ones do you love?
I forgot The Perry Bible Fellowship. That mistake will not happen again! Unfortunately, it seems PBF is sort of down right now. :(